Pharmaceutical Sciences Faculty Publications
Metabolic Profiling for the Detection of Bladder Cancer
Document Type
Article
Publication Date
2-1-2011
Journal Title
Current Urology Reports
ISSN
1534-6285
Volume
12
Issue
1
First Page
34
Last Page
40
DOI
10.1007/s11934-010-0151-3
PubMed ID
21061098
Abstract
The development and progression of many human diseases often result in changes in gene expression and protein and metabolite concentrations. Changes at the protein and metabolite level often are detectable in biological fluids and tissues before the appearance of clinical symptoms, rendering them useful diagnostic and prognostic biomarkers. As with many conditions, the discovery of a sensitive and specific urinary biomarker for bladder cancer would save lives and reduce the suffering due to this condition. A number of potential urinary protein biomarkers for bladder cancer have been identified, but they lack the sensitivity and specificity required to replace cystoscopy and histopathology. We discuss the use of mass spectrometry and nuclear magnetic resonance spectroscopy for the detection of metabolites in biological samples, comment on their advantages and limitations, and discuss recently published work in urine metabolic profiling for bladder cancer detection.
Keywords
Magnetic resonance spectroscopy, metabolome, urinary bladder neoplasms
Recommended Citation
Van, Que N.; Veenstra, Timothy D.; and Issaq, Haleem J., "Metabolic Profiling for the Detection of Bladder Cancer" (2011). Pharmaceutical Sciences Faculty Publications. 243.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/243