Pharmaceutical Sciences Faculty Publications
Document Type
Article
Publication Date
11-1-2010
Journal Title
Archives of Physical Medicine and Rehabilitation
ISSN
1532-821X
Volume
91
Issue
11
First Page
1667
Last Page
1672
DOI
10.1016/j.apmr.2010.05.018
PubMed ID
21044710
Abstract
Recent advances in genomics, proteomics, and biotechnology have provided unprecedented opportunities for translational research and personalized medicine. Human biospecimens and biofluids represent an important resource from which molecular data can be generated to detect and classify injury and to identify molecular mechanisms and therapeutic targets. To date, there has been considerable variability in biospecimen and biofluid collection, storage, and processing in traumatic brain injury (TBI) studies. To realize the full potential of this important resource, standardization and adoption of best practice guidelines are required to insure the quality and consistency of these specimens. The aim of the Biospecimens and Biomarkers Working Group was to provide recommendations for core data elements for TBI research and develop best practice guidelines to standardize the quality and accessibility of these specimens. Consensus recommendations were developed through interactions with focus groups and input from stakeholders participating in the interagency workshop on Standardization of Data Collection in TBI and Psychological Health held in Washington, DC, in March 2009. With the adoption of these standards and best practices, future investigators will be able to obtain data across multiple studies with reduced costs and effort and accelerate the progress of genomic, proteomic, and metabolomic research in TBI.
Keywords
Biomarkers, biopsy, brain injuries
Recommended Citation
Manley, Geoffrey T.; Diaz-Arrastia, Ramon; Brophy, Mary; Engel, Doortje; Goodman, Clay; Gwinn, Katrina; Veenstra, Timothy D.; Ling, Geoffrey; Ottens, Andrew K.; Tortella, Frank; and Hayes, Ronald L., "Common Data Elements for Traumatic Brain Injury: Recommendations From the Biospecimens and Biomarkers Working Group" (2010). Pharmaceutical Sciences Faculty Publications. 265.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/265