Pharmaceutical Sciences Faculty Publications
Quantitative Measurement of Endogenous Estrogen Metabolites, Risk-Factors for Development of Breast Cancer, in Commercial Milk Products by LC-MS/MS
Document Type
Article
Publication Date
5-1-2009
Journal Title
Journal of Chromatography B
ISSN
1873-376X
Volume
877
Issue
13
First Page
1327
Last Page
1334
DOI
10.1016/j.jchromb.2009.01.032
PubMed ID
19217359
Abstract
Increased levels of estrogen metabolites (EM) are associated with cancers of the reproductive system. One potential dietary source of EM is milk. In this study, the absolute quantities of unconjugated (free) and unconjugated plus conjugated (total) EM were measured in a variety of commercial milks (whole, 2%, skim, and buttermilk). The results show that the milk products tested contain considerable levels of EM; however, the levels of unconjugated EM in skim milk were substantially lower than that observed in whole milk, 2% milk, and buttermilk. Whole milk contained the lowest overall levels of EM while buttermilk contained the highest. As anticipated, soy milk did not contain the mammalian EM measured using this method. The relatively high levels of catechol estrogens detected in milk products support the theory that milk consumption is a source of EM and their ingestion may have a dietary influence on cancer risk.
Keywords
Breast neoplasms, calibration, chromatography, liquid, estrogens, milk, risk factors, tandem mass spectrometry
Recommended Citation
Farlow, Daniel W.; Xu, Xia; and Veenstra, Timothy D., "Quantitative Measurement of Endogenous Estrogen Metabolites, Risk-Factors for Development of Breast Cancer, in Commercial Milk Products by LC-MS/MS" (2009). Pharmaceutical Sciences Faculty Publications. 286.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/286