Pharmaceutical Sciences Faculty Publications
Proteomic Analysis of Extracellular Matrix and Vesicles
Document Type
Article
Publication Date
2-15-2009
Journal Title
Journal of Proteomics
ISSN
1874-3919
Volume
72
Issue
1
First Page
34
Last Page
45
PubMed ID
19068243
PubMed Central® ID
10.1016/j.jprot.2008.11.011
Abstract
The extracellular matrix (ECM) is the connective tissue component generated and secreted by cells to provide structural and functional support, while extracellular vesicles are distinct membrane-enclosed structures present outside of eucaryotic cells that carry out distinct biological functions. Different cell types release distinct populations of vesicles that fulfill various functions. Exosomes are vesicles commonly secreted by a variety of cells, whereas matrix vesicles (MVs) are specifically produced and secreted by bone cells to facilitate the formation of the ECM. This article focuses on the characteristics of the ECM and extracellular vesicles, and reviews the latest progress in applying proteomic technologies to analyze these features. The findings and implications in developmental biology, tumor biology, immunology, biomarker discovery, and vaccine research are also discussed.
Keywords
Biomarkers, tumor, exocytosis, extracellular matrix, extracellular matrix proteins, glycoproteins, proteome, secretory vesicles
Recommended Citation
Xiao, Zhen; Blonder, Josip; Zhou, Ming; and Veenstra, Timothy D., "Proteomic Analysis of Extracellular Matrix and Vesicles" (2009). Pharmaceutical Sciences Faculty Publications. 300.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/300