Pharmaceutical Sciences Faculty Publications
Document Type
Article
Publication Date
1-20-2009
Journal Title
Genome Medicine
ISSN
1756-994X
Volume
1
Issue
1
First Page
5
Last Page
5
DOI
10.1186/gm5
PubMed ID
19348692
PubMed Central® ID
PMC2651582
Abstract
Metabolic profiling using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) is integral to the rapidly expanding field of metabolomics, which is making progress in toxicology, plant science and various diseases, including cancer. In the area of oncology and metabolic phenotyping, researchers have probed the known changes in malignant cellular pathways using new experimental techniques to gain more insights, and others are exploiting these same cellular pathways for therapeutic drug targets and for novel cancer biomarkers, with the ultimate goal of translation to the clinic. Here, we discuss the challenges and opportunities in metabolic phenotyping for discovering novel cancer biomarkers, and we assess the clinical applicability of MS and NMR.
Keywords
Genome, medicine, bench, bedside, metabolic profiling, cancer, research
Recommended Citation
Van, Que N. and Veenstra, Timothy D., "How Close is the Bench to the Bedside? Metabolic Profiling in Cancer Research" (2009). Pharmaceutical Sciences Faculty Publications. 313.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/313
