Pharmaceutical Sciences Faculty Publications

Targeted Proteomics for Validation of Biomarkers in Clinical Samples

Document Type

Article

Publication Date

3-1-2009

Journal Title

Briefings in Functional Genomics & Proteomics

ISSN

1477-4062

Volume

8

Issue

2

First Page

126

Last Page

135

DOI

10.1093/bfgp/eln050

PubMed ID

19109305

PubMed Central® ID

PMC2722261

Abstract

The rapid rise and application of proteomic technologies has resulted in an exponential increase in the number of proteins that have been discovered and presented as 'potential' biomarkers for specific diseases. Unfortunately, the number of biomarkers approved for use by the Food and Drug Administration has not risen in likewise manner. While there are a number of reasons for this discrepancy, this glut of 'potential' biomarkers also indicates the need for validation methods to confirm or refute their utility in clinical diagnostics. For this reason, the emphasis on developing methods to target and measure the absolute quantity of specific proteins and peptides in complex proteomic samples has grown.

Keywords

Biomarkers, computational biology, gene expression profiling, genomics, ions, mass spectrometry, peptides, proteins, proteome, proteomics, receptor, ErbB-2, reproducibility of results

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