Pharmaceutical Sciences Faculty Publications

Title

Clinical Proteomic Applications of Formalin-Fixed Paraffin-Embedded Tissues

Document Type

Article

Publication Date

3-1-2009

Journal Title

Clinics in Laboratory Medicine

ISSN

1557-9832

Volume

29

Issue

1

First Page

101

Last Page

113

DOI

10.1016/j.cll.2009.01.006

PubMed ID

19389554

Abstract

Although proteomic technology has proved to be extremely powerful in basic research, its impact has not been as great in the clinical laboratory. The future, however, looks extremely positive because technologies, such as mass spectrometry and tissue microarrays, have continued to improve over the past several years. One of the most exciting developments, particularly in the area of mass spectrometry, is the ability to examine formalin-fixed paraffin-embedded tissue using these technologies. The almost inexhaustible supply of these tissues will enable proteomic laboratories access to clinically important specimens that will undoubtedly lead to a number of important discoveries in the near future.

Keywords

Biomarkers, formaldehyde, immunohistochemistry, mass spectrometry, neoplasms, paraffin embedding, proteomics, reproducibility of results, tissue array analysis

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