Pharmaceutical Sciences Faculty Publications

Document Type

Article

Publication Date

4-1-2008

Journal Title

BioTechniques

ISSN

0736-6205

Volume

44

Issue

5

First Page

667

Last Page

668

DOI

10.2144/000112791

PubMed ID

18474043

Abstract

While definitely not a new technology, mass spectrometry (MS) has seen incredible growth over the past 25 years. Mass spectrometry has rapidly evolved to the forefront of analytical techniques; its ability to analyze proteins is the major driving force in the field of proteomics. MS instrumentation has increased approximately 5-fold in sensitivity every three years. The level of performance that is achievable with MS today allows scientists to study proteins in ways that were inconceivable a quarter century ago. This review of the history of MS over the past 25 years is timely in that it encompasses two of the biggest developments, electrospray and matrix-assisted laser desorption/ionization (MALDI), which have enabled many of the uses of this technology today.

Keywords

Mass spectrometry, peptide mapping, proteomics

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