Pharmaceutical Sciences Faculty Publications

Title

Biomarkers: Mining the Biofluid Proteome

Document Type

Article

Publication Date

4-1-2005

Journal Title

Molecular & Cellular Proteomics

ISSN

1535-9476

Volume

4

Issue

4

First Page

409

Last Page

418

DOI

10.1074/mcp.M500006-MCP200

PubMed ID

15684407

Abstract

Proteomics has brought with it the hope of identifying novel biomarkers for diseases such as cancer. This hope is built on the ability of proteomic technologies, such as mass spectrometry (MS), to identify hundreds of proteins in complex biofluids such as plasma and serum. There are many factors that make this research very challenging beginning with the lack of standardization of sample collection and continuing through the entire analytical process. Fortunately the advances made in the characterization of biofluids using proteomic techniques have been rapid and suggest that these mainly discovery driven approaches will lead to the development of highly specific platforms for diagnosing diseases and monitoring responses to different treatments in the near future.

Keywords

Biomarkers, blood proteins, humans, proteome, proteomics

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