Pharmaceutical Sciences Faculty Publications
Proteomics Approaches to Biomarker Detection
Document Type
Article
Publication Date
5-1-2005
Journal Title
Briefings in Functional Genomics & Proteomics
ISSN
1473-9550
Volume
4
Issue
1
First Page
69
Last Page
75
DOI
10.1093/bfgp/4.1.69
PubMed ID
15975266
Abstract
The development of mass spectrometry (MS) technologies has brought the ability to gather massive amounts of data characterising the proteomes of complex mixtures. A major focus in proteomics is to leverage this data-gathering capability to conduct comparative analyses of biofluids from healthy and disease-affected patients for the identification of highly specific biomarkers and/or the development of MS-based diagnostic platforms. Much effort has gone into optimising the biofluid proteome coverage that can be obtained using these technologies, leaving proteomics poised to make an important impact in disease diagnostics in the future.
Keywords
Biomarkers, chromatography, ion exchange, electrophoresis, gel, mass spectrometry, proteome, proteomics
Recommended Citation
Zhou, Ming; Conrads, Thomas P.; and Veenstra, Timothy D., "Proteomics Approaches to Biomarker Detection" (2005). Pharmaceutical Sciences Faculty Publications. 426.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/426