Pharmaceutical Sciences Faculty Publications

Title

Proteomics Approaches to Biomarker Detection

Document Type

Article

Publication Date

5-1-2005

Journal Title

Briefings in Functional Genomics & Proteomics

ISSN

1473-9550

Volume

4

Issue

1

First Page

69

Last Page

75

DOI

10.1093/bfgp/4.1.69

PubMed ID

15975266

Abstract

The development of mass spectrometry (MS) technologies has brought the ability to gather massive amounts of data characterising the proteomes of complex mixtures. A major focus in proteomics is to leverage this data-gathering capability to conduct comparative analyses of biofluids from healthy and disease-affected patients for the identification of highly specific biomarkers and/or the development of MS-based diagnostic platforms. Much effort has gone into optimising the biofluid proteome coverage that can be obtained using these technologies, leaving proteomics poised to make an important impact in disease diagnostics in the future.

Keywords

Biomarkers, chromatography, ion exchange, electrophoresis, gel, mass spectrometry, proteome, proteomics

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