Pharmaceutical Sciences Faculty Publications

Proteomic Patterns for Early Cancer Detection

Document Type

Article

Publication Date

10-15-2004

Journal Title

Drug Discovery Today

ISSN

1359-6446

Volume

9

Issue

20

First Page

889

Last Page

897

DOI

10.1016/S1359-6446(04)03246-5

PubMed ID

15475322

Abstract

The advent of proteomics has brought with it the hope of discovering novel biomarkers that can be used to diagnose diseases, predict susceptibility, and monitor progression. Much of this effort has focused on the mass spectral identification of the thousands of proteins that populate complex biosystems such as serum and tissues. A revolutionary approach in proteomic pattern analysis has emerged as an effective method for the early diagnosis of diseases such as ovarian, breast, and prostate cancer. This technology is capable of analyzing hundreds of clinical samples per day and has the potential to be a novel, highly sensitive diagnostic tool for the early detection of diseases, or as a predictor of response to therapy.

Keywords

Biomarkers, tumor, mass spectrometry, neoplasms, proteomics

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