Pharmaceutical Sciences Faculty Publications
Importance of Communication Between Producers and Consumers of Publicly Available Experimental Data
Document Type
Article
Publication Date
2-16-2005
Journal Title
Journal of the National Cancer Institute
ISSN
1460-2105
Volume
97
Issue
4
First Page
310
Last Page
314
DOI
10.1093/jnci/dji053
PubMed ID
15713967
Abstract
The application of mass spectrometry to discover new cancer biomarkers is in its infancy. Many of these new markers are low-abundance proteins that exist as fragments associated with carrier proteins. Although reproducibility is key to the use of mass spectrometry for ion fingerprint analysis, the scientific community has yet to establish a common platform or standardized operating procedures that are necessary for intra- and inter-laboratory comparison. In an effort to assist others who are perfecting mass spectrometry platforms for profiling, ongoing experimental data were posted for public consumption. An unintended consequence of unrestricted access to experimental data is the risk of inappropriate conclusions drawn and publicly disseminated that could have been avoided by communication between the producers and consumers of the data. Such disputes, however, should not divert us from the validation of this promising new approach.
Keywords
Biomarkers, tumor, communication, DNA fingerprinting, interprofessional relations, laboratories, mass spectrometry, neoplasms, proteome, reproducibility of results
Recommended Citation
Liotta, Lance A.; Lowenthal, Mark; Mehta, Arpita; Conrads, Thomas P.; Veenstra, Timothy D.; Fishman, David A.; and Petricoin, Emanuel F., "Importance of Communication Between Producers and Consumers of Publicly Available Experimental Data" (2005). Pharmaceutical Sciences Faculty Publications. 447.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/447