Pharmaceutical Sciences Faculty Publications
Serum Proteomic Profiles Suggest Celecoxib-Modulated Targets and Response Predictors
Document Type
Article
Publication Date
4-15-2004
Journal Title
Cancer Research
ISSN
0008-5472
Volume
64
Issue
8
First Page
2904
Last Page
2909
DOI
10.1158/0008-5472.can-03-3754
PubMed ID
15087410
Abstract
Cyclooxygenase-2 is a valid target for cancer prevention and treatment. This has been shown in preclinical and clinical cancer prevention studies by using a cyclooxygenase-2 inhibitor, celecoxib. When used in a randomized cancer prevention clinical trial on patients with the inherited autosomal dominant condition, familial adenomatous polyposis, celecoxib proved efficacious. However, a remarkable heterogeneity in patients' responses to the chemopreventive effects of celecoxib was observed. Proteomic profiling of sera from these patients identified several markers, the expression of which was specifically modulated after treatment with celecoxib. A decision tree algorithm identified classifiers for response to celecoxib with relatively high sensitivity but moderate to low specificity. In particular, a spectral feature at m/z 16,961.4 was identified as a strong discriminator between response and nonresponse to celecoxib at the highest dose.
Keywords
Adenomatous polyposis coli, anticarcinogenic agents, blood proteins, celecoxib, mass spectrometry, proteome, pyrazoles, sulfonamides
Recommended Citation
Xiao, Zhen; Luke, Brian T.; Izmirlian, Grant; Umar, Asad; Lynch, Patrick M.; Phillips, Robin K.S.; Patterson, Sherri; Conrads, Thomas P.; Veenstra, Timothy D.; Greenwald, Peter; and et al, "Serum Proteomic Profiles Suggest Celecoxib-Modulated Targets and Response Predictors" (2004). Pharmaceutical Sciences Faculty Publications. 483.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/483