Pharmaceutical Sciences Faculty Publications
Distribution of 1,25-Dihydroxyvitamin D3 Receptor Immunoreactivity in the Rat Olfactory System
Document Type
Article
Publication Date
10-1-1999
Journal Title
Cellular and Molecular Neurobiology
ISSN
0272-4340
Volume
19
Issue
5
First Page
613
Last Page
624
DOI
10.1023/a:1006932418220
PubMed ID
10384259
Abstract
1. The rat olfactory system contains numerous target sites for 1,25-dihydroxyvitamin D3, as determined by receptor protein (VDR) immunocytochemistry and in situ hybridization. 2. Nuclear and cytoplasmic VDR immunoreactivity as well as the corresponding hybridization signal was observed in neurons in the olfactory epithelium, the olfactory bulb, and throughout the limbic system in locations also known to be glucocorticoid targets. 3. The widespread distribution of VDR indicates the distinct functional importance of 1,25-dihydroxyvitamin D3 for olfactory perception.
Keywords
Olfactory bulb, olfactory pathways, olfactory receptor neurons, rats, Sprague-Dawley, calcitriol
Recommended Citation
Glaser, Sirit D.; Veenstra, Timothy D.; Jirikowski, Gustav F.; and Prüfer, Kirsten, "Distribution of 1,25-Dihydroxyvitamin D3 Receptor Immunoreactivity in the Rat Olfactory System" (1999). Pharmaceutical Sciences Faculty Publications. 536.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/536