Pharmaceutical Sciences Faculty Publications

Title

Distribution of 1,25-Dihydroxyvitamin D3 Receptor Immunoreactivity in the Rat Olfactory System

Document Type

Article

Publication Date

10-1-1999

Journal Title

Cellular and Molecular Neurobiology

ISSN

0272-4340

Volume

19

Issue

5

First Page

613

Last Page

624

DOI

10.1023/a:1006932418220

PubMed ID

10384259

Abstract

1. The rat olfactory system contains numerous target sites for 1,25-dihydroxyvitamin D3, as determined by receptor protein (VDR) immunocytochemistry and in situ hybridization. 2. Nuclear and cytoplasmic VDR immunoreactivity as well as the corresponding hybridization signal was observed in neurons in the olfactory epithelium, the olfactory bulb, and throughout the limbic system in locations also known to be glucocorticoid targets. 3. The widespread distribution of VDR indicates the distinct functional importance of 1,25-dihydroxyvitamin D3 for olfactory perception.

Keywords

Olfactory bulb, olfactory pathways, olfactory receptor neurons, rats, Sprague-Dawley, calcitriol

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