Prevention of Vertebrate Neuronal Death by the crmA Gene

Authors

Valeria Gagliardini, Harvard University
Pierre-Alain Fernandez, Harvard University
Robert K.K. Lee, Harvard University
Hans C.A. Drexler, Harvard University
Rocco J. Rotello, Cedarville UniversityFollow
Mark C. Fishman, Harvard University
Junying Yuan, Massachusetts General Hospital

Document Type

Article

Publication Date

2-11-1994

Journal Title

Science

Volume

263

Issue

5148

First Page

826

Last Page

828

DOI

http://dx.doi.org/10.1126/science.8303301

PubMed ID

8303301

Abstract

Interleukin-1β converting enzyme (ICE) is a mammalian homolog of CED-3, a protein required for programmed cell death in the nematode Caenorhabditis elegans. The activity of ICE can be specifically inhibited by the product of crmA, a cytokine response modifier gene encoded by cowpox virus. Microinjection of the crmA gene into chicken dorsal root ganglion neurons was found to prevent cell death induced by deprivation of nerve growth factor. Thus, ICE is likely to participate in neuronal death in vertebrates.

Keywords

CrmA, genes, genetics

Recommended Citation

Gagliardini, Valeria; Fernandez, Pierre-Alain; Lee, Robert K.K.; Drexler, Hans C.A.; Rotello, Rocco J.; Fishman, Mark C.; and Yuan, Junying, "Prevention of Vertebrate Neuronal Death by the crmA Gene" (1994). Pharmaceutical Sciences Faculty Publications. 68.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/68