Pharmacy Practice Faculty Publications
Association of Diuretic Use and Overactive Bladder Syndrome in Older Adults: A Propensity Score Analysis
Document Type
Article
Publication Date
7-2009
Journal Title
Archives of Gerontology and Geriatrics
ISSN
1872-6976
Volume
49
Issue
1
First Page
64
Last Page
68
DOI
http://dx.doi.org/10.1016/j.archger.2008.05.002
PubMed ID
18752858
PubMed Central® ID
PMC2720316
Abstract
Diuretic use and overactive bladder syndrome are common in older adults. However, the relationship between the two has not been well studied. Data were collected by self-administered questionnaires including the Urge Urinary Distress Inventory (Urge-UDI) and the Urge Incontinence Impact Questionnaire (Urge-IIQ), and by outpatient chart abstraction. Patients (n = 172) had a mean age of 79 ± 7.5 (±S.D.), 76% were women, and 48% were African Americans; 76% had hypertension, 32% had heart failure, and 66% were receiving diuretics (57% loop diuretics). Overall, 72%, 68%, and 73% of patients, respectively, reported urinary frequency, urgency and urge incontinence. Diuretic use was associated with increased frequency (81% versus 55% non-diuretic; odds ratio (OR) = 3.48; 95% confidence interval (CI) = 1.73–7.03) and urgency (74% versus 57% non-diuretic; OR = 2.17; 95% CI = 1.11–4.24) but not with incontinence (OR = 1.74; 95% CI = 0.87–3.50). When adjusted for propensity scores, diuretic use had independent associations with frequency (adjusted OR = 3.09; 95% CI = 1.20–7.97) and urgency (adjusted OR = 2.50; 95% CI = 1.00–6.27). In addition to frequency and urgency, loop diuretic use was also associated with incontinence (OR = 2.54; 95% CI = 1.09–5.91), which lost significance after propensity adjustment (adjusted OR = 1.88; 95% CI = 0.57–6.17). Overall summary mean Urge-IIQ score was 1.83 ± 0.85 with 1.75 ± 0.86, 1.68 ± 0.76, and 2.03 ± 0.88, respectively, for no diuretic, non-loop, and loop-diuretic patients (one-way analysis of variance (ANOVA) p = 0.063). Overactive bladder symptoms were common among ambulatory older adults and were associated with diuretic use, and had stronger associations with loop diuretic use.
Keywords
Diuretic use, overactive bladder, quality of life, propensity score, older adults
Recommended Citation
Ekundayo, O. James; Markland, Alayne; Lefante, Christina; Sui, Xuemei; Goode, Patricia S.; Allman, Richard M.; Ali, Mahmud; Wahle, Christy; Thornton, Phillip L.; and Ahmed, Ali, "Association of Diuretic Use and Overactive Bladder Syndrome in Older Adults: A Propensity Score Analysis" (2009). Pharmacy Practice Faculty Publications. 234.
https://digitalcommons.cedarville.edu/pharmacy_practice_publications/234
