Pharmacy Practice Faculty Publications
Document Type
Article
Publication Date
9-2012
Journal Title
Pediatric Transplantation
ISSN
1399-3046
Volume
16
Issue
6
First Page
E217
Last Page
E220
DOI
http://dx.doi.org/10.1111/j.1399-3046.2011.01559.x
PubMed ID
21883747
Abstract
The shared metabolism of PPIs and tacrolimus through the CYP enzyme system has been associated with clinically significant drug interactions, especially in patients who are classified as CYP 2C19 PMs. However, existing data are conflicting, indicating that a single mechanism does not account for all interactions. A drug interaction between tacrolimus and omeprazole, esomeprazole, but not lansoprazole, occurred in an 18-yr-old female kidney transplant recipient classified as a CYP 2C19 extensive (normal) metabolizer. This case suggests that further research is needed to establish the definitive mechanism of this potentially serious drug–drug interaction. Physicians prescribing PPIs in organ transplant recipients with tacrolimus immunosuppression should consider close pharmacokinetic monitoring of tacrolimus when starting or switching a PPI.
Keywords
Tacrolimus, proton pump inhibitors, drug interaction, pediatric renal transplantation, CYP 2C19, pharmacogenetics, adolescent, aryl hydrocarbon hydroxylases, genetic variation, immunosuppressive agents, kidney transplantation, living donors, pharmacogenetics, polymorphism, treatment outcome
Recommended Citation
Maguire, Michelle; Franz, Thaddeus T.; and Hains, David S., "A Clinically Significant Interaction Between Tacrolimus and Multiple Proton Pump Inhibitors in a Kidney Transplant Recipient" (2012). Pharmacy Practice Faculty Publications. 95.
https://digitalcommons.cedarville.edu/pharmacy_practice_publications/95
Included in
Pediatrics Commons, Pharmacy and Pharmaceutical Sciences Commons, Reproductive and Urinary Physiology Commons
Comments
This is the pre-peer reviewed version of the following article: Maguire, M., Franz, T. and Hains, D. S. (2012), A clinically significant interaction between tacrolimus and multiple proton pump inhibitors in a kidney transplant recipient. Pediatric Transplantation, 16: E217–E220. doi: 10.1111/j.1399-3046.2011.01559.x, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3046.2011.01559.x/abstract.