Type of Submission
Poster
Keywords
pHLIP, Targeted Drug Delivery, Nano-pores, Gramicidin A, Liposomes
Proposal
Extracellular acidity is a universal biomarker for carcinoma and a number of other pathological conditions. It also plays a significant role in cell functioning and proliferation in pathological cells. By exploiting this extracellular acidity, we were able to formulate a novel pH-sensitive nanomedicine for therapeutics & diagnostics using pHLIP® technology. The formulated pHLIP® coated small, unilamellar vesicles have a superior stability and prolong shelf life to deliver hydrophobic agents to pathological sites by safer and more effective means.
The right balance of ions in intracellular and extracellular spaces is vital for regular cell functioning. This ion balance helps to maintain the required membrane potentials, holding everything within the cell. Any variations in this vital balance of ions could induce the cell death in both healthy and pathological cells. We employ pHLIP® coated small, unilamellar vesicles to deliver nano-pores to cancer cells to disrupt the monovalent cation balance and induce apoptosis. In this work, gramicidin A was used to form monovalent cation conductive nano-pores.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Targeted Delivery of Nano-pores into Cancer Cells Using pHLIP® Coated Liposomes
Extracellular acidity is a universal biomarker for carcinoma and a number of other pathological conditions. It also plays a significant role in cell functioning and proliferation in pathological cells. By exploiting this extracellular acidity, we were able to formulate a novel pH-sensitive nanomedicine for therapeutics & diagnostics using pHLIP® technology. The formulated pHLIP® coated small, unilamellar vesicles have a superior stability and prolong shelf life to deliver hydrophobic agents to pathological sites by safer and more effective means.
The right balance of ions in intracellular and extracellular spaces is vital for regular cell functioning. This ion balance helps to maintain the required membrane potentials, holding everything within the cell. Any variations in this vital balance of ions could induce the cell death in both healthy and pathological cells. We employ pHLIP® coated small, unilamellar vesicles to deliver nano-pores to cancer cells to disrupt the monovalent cation balance and induce apoptosis. In this work, gramicidin A was used to form monovalent cation conductive nano-pores.
