Science and Mathematics Faculty Publications

Advanced Targeted Nanomedicine

Document Type

Article

Publication Date

5-10-2016

Journal Title

Journal of Biotechnology

ISSN

0168-1656

Volume

225

First Page

88

Last Page

97

DOI

10.1016/j.jbiotec.2015.01.009

Abstract

Targeted drug delivery has been the major topic in drug formulation and delivery. As nanomedicine emerges to create nano scale therapeutics and diagnostics, it is still essential to embed targeting capability to these novel systems to make them useful. Here we discuss various targeting approaches for delivery of therapeutic and diagnostic nano materials in view of search for more universal methods to target diseased tissues. Many diseases are accompanied with hypoxia and acidosis. Coating nanoparticles with pH Low Insertion Peptides (pHLIPs) increases efficiency of targeting acidic diseased tissues. It has been showing promising results to create future nanotheranostics for cancer and other diseases which are dominating in the present world.

Keywords

pHLIP, Nanomedicine, Passive targeting, Active targeting, Tissue acidity, Environmental targeting

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