Title

Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in Vitro

Document Type

Article

Publication Date

1985

Journal Title

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology

ISSN

0742-8413

Volume

81C

Issue

1

First Page

121

Last Page

124

DOI

http://dx.doi.org/10.1016/0742-8413(85)90101-x

Abstract

1. The present study has evaluated, in vitro, alpha 1-adrenergic receptor mediated responses in submandibular cells from young adult and aged rats.

2. Submandibular glands from different aged rats possess a similar number of alpha 1-adrenergic receptors that display comparable binding characteristics.

3. Following alpha 1-adrenergic stimulation, cells from both groups of rats show a similar ability to mobilize intracellular Ca2+ (45Ca2+ time course, agonist dose-response) and to elicit a functional response (inhibition of protein synthesis by epinephrine) which reflects Ca2+ mobilization.

Keywords

Adrenergic, submandibular gland, rats, calcium, epinephrine, prazosin, receptors

Comments

Journal currently known as Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

PubMed ID

2861036