Stimulation of Glucose Oxidation in Rat Submandibular Gland Cells in Vitro by Analogues of Cyclic AMP

Document Type

Article

Publication Date

1985

Journal Title

Archives of Oral Biology

ISSN

0003-9969

Volume

30

Issue

9

First Page

701

Last Page

703

DOI

http://dx.doi.org/10.1016/0003-9969(85)90159-1

Abstract

Secretion from salivary glands, following autonomic stimulation, is energy-dependent. Rat submandibular gland cells, when treated in vitro with both alpha- and beta-adrenergic agonists, showed increased glucose oxidation. The effects of alpha-adrenergic agents on glucose metabolism can be mimicked by non-receptor mobilization of Ca2+. Analogues of cyclic AMP were capable of elevating glucose metabolism to nearly the same extent as beta-adrenergic agonists.

Keywords

Submandibular gland, salivary secretion, glucose, rats, cyclic AMP, stimulation, in vitro

PubMed ID

3000325

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