Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in Vitro

Authors

B. J. Baum
Brian L. Kuyatt, Cedarville UniversityFollow
Y. Helman
M. V. Gee
G. S. Roth

Document Type

Article

Publication Date

1985

Journal Title

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology

ISSN

0742-8413

Volume

81C

Issue

1

First Page

121

Last Page

124

DOI

http://dx.doi.org/10.1016/0742-8413(85)90101-x

Abstract

1. The present study has evaluated, in vitro, alpha 1-adrenergic receptor mediated responses in submandibular cells from young adult and aged rats.

2. Submandibular glands from different aged rats possess a similar number of alpha 1-adrenergic receptors that display comparable binding characteristics.

3. Following alpha 1-adrenergic stimulation, cells from both groups of rats show a similar ability to mobilize intracellular Ca2+ (45Ca2+ time course, agonist dose-response) and to elicit a functional response (inhibition of protein synthesis by epinephrine) which reflects Ca2+ mobilization.

Keywords

Adrenergic, submandibular gland, rats, calcium, epinephrine, prazosin, receptors

Comments

Journal currently known as Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

PubMed ID

2861036

Recommended Citation

Baum, B. J.; Kuyatt, Brian L.; Helman, Y.; Gee, M. V.; and Roth, G. S., "Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in Vitro" (1985). Center for Teaching and Learning Publications. 5.
https://digitalcommons.cedarville.edu/ctl_publications/5