"Pharmacological Evidence Favouring the Folkloric Use of <em>Diospyros " by B. Adzu, Samson Amos et al.
 

Pharmaceutical Sciences Faculty Publications

Pharmacological Evidence Favouring the Folkloric Use of Diospyros mespiliformis Hochst in the Relief of Pain and Fever

Document Type

Article

Publication Date

10-2002

Journal Title

Journal of Ethnopharmacology

ISSN

0378-8741

Volume

82

Issue

2-3

First Page

191

Last Page

195

DOI

http://dx.doi.org/10.1016/s0378-8741(02)00179-4

PubMed ID

12241995

Abstract

The methanol extract of Diospyros mespiliformis was evaluated for its claimed folkloric usage in the relief of pain and fever. Antipyretic, analgesic and anti-inflammatory effects of the extract were evaluated in rats and mice. Studies were carried out on yeast-induced pyrexia in rats, acetic acid-induced writhing in mice, formalin test and egg albumin-induced anti-inflammatory activity in rats. The extract (50 and 100 mg/kg i.p.) gave a potent antipyretic effect for 100 mg/kg and significant activity (P<0.05) against all the analgesic and anti-inflammatory models used. The LD50 of the extract was estimated to be 513.80±33.92 mg/kg i.p. in mice. These results provide support for the use of the plant in relieving pain and fever.

Keywords

Diospyros mespiliformis, antipyretic, analgesic, anti-inflammatory

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