Pharmaceutical Sciences Faculty Publications
Effect of Zizyphus spina-christi Willd Aqueous Extract on the Central Nervous System in Mice
Document Type
Article
Publication Date
2-2002
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741
Volume
79
Issue
1
First Page
13
Last Page
16
DOI
http://dx.doi.org/10.1016/s0378-8741(01)00348-8
PubMed ID
11744289
Abstract
The effects of the aqueous extract of Zizypus spina-christi Willd root bark against exploratory behaviour, spontaneous motor activity (SMA), motor coordination (Rota-rod performance) and pentobarbital-induced hypnosis were investigated in mice. The extract induced a significant (P<0.05) dose-dependent reduction in exploratory behaviour and SMA when administered orally. It also prolonged pentobarbital sleeping time but failed to inhibit motor coordination (rota-rod performance) in the experimental mice. These results suggest that the extract contained some constituents that depress the central nervous system, which may not be due to neuromuscular blockade.
Keywords
Exploratory behaviour, spontaneous motor activity, motor coordination, pentobarbital sleep
Recommended Citation
Adzu, B.; Amos, Samson; Dzarma, S.; Wambebe, C.; and Gamaniel, K., "Effect of Zizyphus spina-christi Willd Aqueous Extract on the Central Nervous System in Mice" (2002). Pharmaceutical Sciences Faculty Publications. 126.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/126