Pharmaceutical Sciences Faculty Publications
Pharmacological Evidence Favouring the Folkloric Use of Diospyros mespiliformis Hochst in the Relief of Pain and Fever
Document Type
Article
Publication Date
10-2002
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741
Volume
82
Issue
2-3
First Page
191
Last Page
195
DOI
http://dx.doi.org/10.1016/s0378-8741(02)00179-4
PubMed ID
12241995
Abstract
The methanol extract of Diospyros mespiliformis was evaluated for its claimed folkloric usage in the relief of pain and fever. Antipyretic, analgesic and anti-inflammatory effects of the extract were evaluated in rats and mice. Studies were carried out on yeast-induced pyrexia in rats, acetic acid-induced writhing in mice, formalin test and egg albumin-induced anti-inflammatory activity in rats. The extract (50 and 100 mg/kg i.p.) gave a potent antipyretic effect for 100 mg/kg and significant activity (P<0.05) against all the analgesic and anti-inflammatory models used. The LD50 of the extract was estimated to be 513.80±33.92 mg/kg i.p. in mice. These results provide support for the use of the plant in relieving pain and fever.
Keywords
Diospyros mespiliformis, antipyretic, analgesic, anti-inflammatory
Recommended Citation
Adzu, B.; Amos, Samson; Dzarma, S.; Muazzam, I.; and Gamaniel, K. S., "Pharmacological Evidence Favouring the Folkloric Use of Diospyros mespiliformis Hochst in the Relief of Pain and Fever" (2002). Pharmaceutical Sciences Faculty Publications. 127.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/127