Pharmaceutical Sciences Faculty Publications

Pharmacological Effects of the Aqueous Extract of Neorautanenia mitis in Rodents

Document Type

Article

Publication Date

9-1-2000

Journal Title

Journal of Ethnopharmacology

ISSN

0378-8741

Volume

72

Issue

1-2

First Page

207

Last Page

214

DOI

http://dx.doi.org/10.1016/s0378-8741(00)00247-6

PubMed ID

10967473

Abstract

The pharmacological effects of the aqueous extract of Neorautanenia mitis (family Papilonaceae) were studied in rodents. Investigations were carried out on acetic acid-induced writhing (pain) in mice and hind paw oedema in rats. The effects of the extract were also studied on the isolated non-pregnant rat uterus and rabbit jejunum. Results showed the extract to possess significant (P<0.05) dose-dependent anti-nociceptive activity between 12.5 and 50.0 mg/kg p.o. in mice and slight anti-inflammatory activity at 25 and 50 mg/kg p.o. in rats. The extract also produced a concentration-dependent inhibition of the normal rhythmic contraction of the isolated non-pregnant rat uterus. It was found to inhibit oxytocin-induced as well as acetylcholine-induced contractions in the rat uterus. The extract also exhibited concentration-dependent inhibition of spontaneous contractions of the rabbit jejunum. Preliminary phytochemical analysis of the extract revealed the presence of saponin glycosides, flavonoids, tannins and alkaloids. The extract had an intraperitoneal (i.p.) LD50 of 282.84±3.2 mg/kg in mice. These data corroborate the traditional use of this plant in the treatment of dysmenorrhea.

Keywords

Neorautanenia mitis, anti-nociceptive, anti-inflammatory, uterine smooth muscle, acetic acid-induced writhing, rat paw oedema, rabbit jejunum

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