Pharmaceutical Sciences Faculty Publications
Neuropharmacological Effect of the Aqueous Extract of Sphaeranthus senegalensis in Mice
Document Type
Article
Publication Date
11-2001
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741
Volume
78
Issue
1
First Page
33
Last Page
37
DOI
http://dx.doi.org/10.1016/s0378-8741(01)00316-6
PubMed ID
11585685
Abstract
Effects of the aqueous extract of Sphaeranthus senegalensis Vaill. (Family: Compositae) were studied on spontaneous motor activity, exploratory behaviour, rota-rod performance and pentobarbital sleeping time in mice. Preliminary phytochemical evaluation and acute toxicity (LD50) values were also studied. The extract (50 and 100 mg/kg p.o.) produced reduction in spontaneous motor activity, exploratory behaviour and motor coordination and prolonged pentobarbital sleeping time. Glycosides, saponins and tannins were shown to be present in the extract. The i.p. LD50 in mice was 2735.61 and 5000 mg/kg orally. The results suggest that the aqueous extract of S. senegalensiscontains some active principles, which may be sedative in nature.
Keywords
Sphaeranthus senegalensis, sedation, spontaneous motor activity, exploratory behaviour, motor coordination, pentobarbital sleeping time
Recommended Citation
Amos, Samson; Adzu, B.; Binda, L.; Wambebe, C.; and Gamaniel, K., "Neuropharmacological Effect of the Aqueous Extract of Sphaeranthus senegalensis in Mice" (2001). Pharmaceutical Sciences Faculty Publications. 125.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/125