Antinociceptive Activity of Zizyphus spina-christi Root Bark Extract

Authors

B. Adzu
Samson Amos, Cedarville UniversityFollow
C. Wambebe
K. Gamaniel

Document Type

Article

Publication Date

5-2001

Journal Title

Fitoterapia

ISSN

0367-326X

Volume

72

Issue

4

First Page

344

Last Page

350

DOI

http://dx.doi.org/10.1016/s0367-326x(00)00289-6

PubMed ID

11395256

Abstract

The antinociceptive effect of the aqueous extract of Zizyphus spina-christi root bark was investigated in mice and rats. Acetic acid-induced writhing, formalin and thermal (hot plate) tests were used. The extract (50 and 100 mg/kg, i.p.) showed a dose-dependent analgesic effect in all the tests used. Its i.p. LD₅₀ in mice was 2236.07 mg/kg.

Keywords

Zizyphus spina-christi, Antinociceptive activity

Comments

Journal also known as Fitoterapia: The Journal for the Study of Medicinal Plants

Recommended Citation

Adzu, B.; Amos, Samson; Wambebe, C.; and Gamaniel, K., "Antinociceptive Activity of Zizyphus spina-christi Root Bark Extract" (2001). Pharmaceutical Sciences Faculty Publications. 135.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/135