Pharmaceutical Sciences Faculty Publications
Neuropharmacological Screening of Diospyros mespiliformis in Mice
Document Type
Article
Publication Date
11-2002
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741
Volume
83
Issue
1-2
First Page
139
Last Page
143
DOI
http://dx.doi.org/10.1016/s0378-8741(02)00249-0
PubMed ID
12413720
Abstract
The neuropharmacological activities of the aqueous extract of Diospyros mespiliformisstem bark were screened in mice. The extracts effect on pentobarbital-induced sleeping time, pentylenetetrazole induced seizure, spontaneous motor activity (SMA), exploratory behaviour, and rota-rod performance (motor coordination) were evaluated. The extract (100 and 200 mg/kg p.o.) produced a significant (P<0.05) prolongation of pentobarbital-induced sleeping time, and reduced the SMA and exploratory behaviour. The extract prolonged onset of the phases of seizure activity but did not protect mice against lethality induced by pentylenetetrazole. It also failed to affect the motor coordination test. These results suggest that the extract contained an agent with neuropharmacological activity that may be sedative in nature.
Keywords
Diospyros mespiliformis, neuropharmacology, mice, anticonvulsants, hypnotics and sedatives
Recommended Citation
Adzu, B.; Amos, Samson; Muazzam, I.; Inyang, U. S.; and Gamaniel, K. S., "Neuropharmacological Screening of Diospyros mespiliformis in Mice" (2002). Pharmaceutical Sciences Faculty Publications. 128.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/128