Pharmaceutical Sciences Faculty Publications
Clinical Proteomics and Biomarker Discovery
Document Type
Article
Publication Date
6-1-2004
Journal Title
Annals of the New York Academy of Sciences
ISSN
0077-8923
Volume
1022
First Page
295
Last Page
305
DOI
10.1196/annals.1318.045
PubMed ID
15251975
Abstract
Early detection of disease generally provides much-improved outcomes by a definitive medical procedure or through lifestyle modification along with specific medical management strategies. For serum biomarkers, which are central to the diagnosis of many diseases, to become truly useful sentinels of pathogenesis, their sensitivity and specificity in both early detection and recurrence monitoring must be improved. Currently, the detection and monitoring of disease markers is based on solitary proteins, and this approach is not always reliable. New classes of biomarkers derived from mass spectroscopy analysis of the low molecular weight proteome have shown improved abilities in the early detection of disease and hence in patient risk stratification and outcome. The development of a modular platform technology with sufficient flexibility and design abstractions allowing for concurrent experimentation, test, and refinement will help speed the progress of mass spectroscopy-derived proteomic pattern-based diagnostics from the scientific laboratory to the medical clinic. For acceptance by scientists, physicians, and regulatory personnel, new bioinformatic tools are essential system components for data management, analysis, and intuitive display of these new and complex data. Clinically engineered mass spectroscopy systems are essential for the further development and validation of multiplexed biomarkers that have shown tremendous promise for the early detection of disease.
Keywords
Biomarkers, cohort studies, computational biology, mass spectrometry, molecular weight, neoplasm proteins, neoplasms, ovarian neoplasms, proteome, proteomics
Recommended Citation
Johann, Donald J.; McGuigan, Michael D.; Patel, Amit R.; Tomov, Stanimire; Ross, Sally; Conrads, Thomas P.; Veenstra, Timothy D.; Fishman, David A.; Whiteley, Gordon R.; Petricoin, Emanuel F.; and et al, "Clinical Proteomics and Biomarker Discovery" (2004). Pharmaceutical Sciences Faculty Publications. 450.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/450