Pharmaceutical Sciences Faculty Publications
Behavioural Effects in Rodents of Methyl Angolensate: a Triterpenoid Isolated from Entandrophragma angolense
Document Type
Article
Publication Date
8-2002
Journal Title
Pharmacology & Toxicology
Volume
91
Issue
2
First Page
71
Last Page
76
DOI
10.1034/j.1600-0773.2002.910205.x
Abstract
Behavioral effects of methyl angolensate were investigated in mice and rats. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behaviour, exploratory activity and apomorphine – induced climbing studies in mice were evaluated. The results revealed that methyl angolensate reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time in rats and attenuated amphetamine-induced stereotype behaviour in rats. Methyl angolensate also decreased exploratory activity in mice and reduced the rate of apomorphine-induced climbing in mice at the doses tested. It is suggested that methyl angolensate possesses some biologically active principles that are sedative in nature.
Keywords
Methyl angolensate, entandrophragma angolense, motor activity, rodents, behavior, behavioural effects
Recommended Citation
Amos, Samson; Abayomi, Orisadipe; Binda, Lucy; Martins, Emeje; Akinbobola, Adesomoju; Okogun, Joseph; Akah, Peter; Wambebe, Charles; and Gamaniel, Karniyus, "Behavioural Effects in Rodents of Methyl Angolensate: a Triterpenoid Isolated from Entandrophragma angolense" (2002). Pharmaceutical Sciences Faculty Publications. 99.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/99
