Effect of Zizyphus spina-christi Willd Aqueous Extract on the Central Nervous System in Mice
Journal of Ethnopharmacology
The effects of the aqueous extract of Zizypus spina-christi Willd root bark against exploratory behaviour, spontaneous motor activity (SMA), motor coordination (Rota-rod performance) and pentobarbital-induced hypnosis were investigated in mice. The extract induced a significant (P<0.05) dose-dependent reduction in exploratory behaviour and SMA when administered orally. It also prolonged pentobarbital sleeping time but failed to inhibit motor coordination (rota-rod performance) in the experimental mice. These results suggest that the extract contained some constituents that depress the central nervous system, which may not be due to neuromuscular blockade.
Exploratory behaviour, spontaneous motor activity, motor coordination, pentobarbital sleep
Adzu, B.; Amos, Samson; Dzarma, S.; Wambebe, C.; and Gamaniel, K., "Effect of Zizyphus spina-christi Willd Aqueous Extract on the Central Nervous System in Mice" (2002). Pharmaceutical Sciences Faculty Publications. 126.