Department/School of the Primary Author

Science and Mathematics


MicroRNA, glioblastoma, cancer therapeutics, biomarkers




MicroRNA (miRNA) is an epigenetic factor that plays an important role in the post-transcriptional regulation of gene and protein expression. Recent research has shown that in many types of cancer, differentially expressed levels of certain types of miRNA are significantly correlated with the transformation of and ongoing issues caused by cancer cells. Specifically, in Glioblastoma, one of the most lethal and aggressive human cancers, differential levels of miRNAs contribute to the cell’s lack of pro-apoptotic gene presence and its high resistance to current treatments. Results from current studies could provide information about which microRNAs are differentially expressed in glioblastoma when compared to normal astrocytes. Differentially expressed microRNAs may be used as a biomarker for diagnosis or a potential therapeutic target for Glioblastoma treatment.

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