Pharmaceutical Sciences Faculty Publications

 

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Submissions from 2004

Proteomic Patterns as a Diagnostic Tool for Early-Stage Cancer: A Review of Its Progress to a Clinically Relevant Tool, Thomas P. Conrads, Brian L. Hood, Haleem J. Issaq, and Timothy D. Veenstra

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The Utility of Proteomic Patterns for the Diagnosis of Cancer, Thomas P. Conrads and Timothy D. Veenstra

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High-resolution serum proteomic features for ovarian cancer detection., T. P. Conrads, V. A. Fusaro, S. Ross, D. Johann, V. Rajapakse, B. A. Hitt, S. M. Steinberg, E. C. Kohn, D. A. Fishman, Timothy D. Veenstra, and et al

An Introduction to Proteomics, B. L. Hood, Timothy D. Veenstra, and T. P. Conrads

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Sheathless Electrospray Ionization Interfaces for Capillary Electrophoresis-Mass Spectrometric Detection Advantages and Limitations, Haleem J. Issaq, George M. Janini, King C. Chan, and Timothy D. Veenstra

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Two‐Dimensional Liquid Chromatography‐Capillary Zone Electrophoresis‐Sheathless Electrospray Ionization‐Mass Spectrometry: Evaluation for Peptide Analysis and Protein Identification, George M. Janini, King C. Chan, Thomas P. Conrads, Haleem J. Issaq, and Timothy D. Veenstra

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Clinical Proteomics and Biomarker Discovery, Donald J. Johann, Michael D. McGuigan, Amit R. Patel, Stanimire Tomov, Sally Ross, Thomas P. Conrads, Timothy D. Veenstra, David A. Fishman, Gordon R. Whiteley, Emanuel F. Petricoin, and et al

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Proteome Analysis of DNA Damage-Induced Neuronal Death Using High Throughput Mass Spectrometry, Mark D. Johnson, Li-Rong Yu, Thomas P. Conrads, Yoshito Kinoshita, Takuma Uo, Jesse D. Matthews, Sang-Won Lee, Richard D. Smith, Timothy D. Veenstra, and Richard S. Morrison

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Coordination of Medicinal Chemistry with an Integrated Pharmacology and Therapeutics Course Sequence and Combined Recitation Course Structure, Nancy E. Kawahara, Rebecca J. Gryka, Barry Bleidt, Avis Ericson, and Bruce Currie

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An Antiproliferative Factor from Interstitial Cystitis Patients is a Frizzled 8 Protein-Related Sialoglycopeptide, Susan K. Keay, Zoltan Szekely, Thomas P. Conrads, Timothy D. Veenstra, Joseph J. Barchi, Chen-Ou Zhang, Kristopher R. Koch, and Christopher J. Michejda

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Serum Proteomic Profiling can Discriminate Prostate Cancer from Benign Prostates in Men with Total Prostate Specific Antigen Levels between 2.5 and 15.0 ng/mL, David K. Ornstein, Walter Rayford, Vincent A. Fusaro, Thomas P. Conrads, Sally J. Ross, Ben A. Hitt, Wesley W. Wiggins, Timothy D. Veenstra, Lance A. Liotta, and Emanuel F. Petricoin

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Lessons from Kitty Hawk: From Feasibility to Routine Clinical Use for the Field of Proteomic Pattern Diagnostics, Emanuel F. Petricoin, David A. Fishman, Thomas P. Conrads, Timothy D. Veenstra, and Lance A. Liotta

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Toxicoproteomics: Serum Proteomic Pattern Diagnostics for Early Detection of Drug Induced Cardiac Toxicities and Cardioprotection, Emanuel F. Petricoin, Vinodh Rajapaske, Eugene H. Herman, Ali M. Arekani, Sally Ross, Donald Johann, Alan Knapton, J. Zhang, Ben A. Hitt, Timothy D. Veenstra, and et al

Integration of Cell Cycle Signals by Swe1 Protein Kinase, K. Sakchaisri, S. Asano, L. R. Yu, J. Shulewitz, C. J. Park, J. E. Park, Y. W. Cho, Timothy D. Veenstra, J. Thorner, and K. S. Lee

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Coupling Morphogenesis to Mitotic Entry, Krisada Sakchaisri, Satoshi Asano, Li-Rong Yu, Mark J. Shulewitz, Chong J. Park, Jung-Eun Park, Young-Wook Cho, Timothy D. Veenstra, Jeremy Thorner, and Kyung S. Lee

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Identification of Oxidized Mitochondrial Proteins in Alcohol-Exposed Human Hepatoma Cells and Mouse Liver, Soo-Kyung Suh, Brian L. Hood, Bong-Jo Kim, Thomas P. Conrads, Timothy D. Veenstra, and Byoung J. Song

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What to do with “One‐Hit Wonders”?, Timothy D. Veenstra, Thomas P. Conrads, and Haleem J. Issaq

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Proteomic Patterns for Early Cancer Detection, Timothy D. Veenstra, Darue A. Prieto, and Thomas P. Conrads

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Proteomics in Diagnostics, Timothy D. Veenstra and Sudhir Srivastava

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Direct Ampholyte-Free Liquid-Phase Isoelectric Peptide Focusing: Application to the Human Serum Proteome, Zhen Xiao, Thomas P. Conrads, David A. Lucas, George M. Janini, Carl F. Schaefer, Kenneth H. Buetow, Haleem J. Issaq, and Timothy D. Veenstra

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Serum Proteomic Profiles Suggest Celecoxib-Modulated Targets and Response Predictors, Zhen Xiao, Brian T. Luke, Grant Izmirlian, Asad Umar, Patrick M. Lynch, Robin K.S. Phillips, Sherri Patterson, Thomas P. Conrads, Timothy D. Veenstra, Peter Greenwald, and et al

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Measuring Seven Endogenous Ketolic Estrogens Simultaneously in Human Urine by High-Performance Liquid Chromatography-Mass Spectrometry, Xia Xu, Larry K. Keefer, David J. Waterhouse, Joseph E. Saavedra, Timothy D. Veenstra, and Regina G. Ziegler

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Caffeine Suppresses Metastasis in a Transgenic Mouse Model: A Prototype Molecule for Prophylaxis of Metastasis, Haiyan Yang, Jessica Rouse, Luanne Lukes, Mindy Lancaster, Timothy D. Veenstra, Ming Zhou, Ying Shi, Yeong-Gwan Park, and Kent Hunter

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Evaluation of the Acid-Cleavable Isotope-Coded Affinity Tag Reagents: Application to Camptothecin-Treated Cortical Neurons, Li-Rong Yu, Thomas P. Conrads, Takuma Uo, Haleem J. Issaq, Richard S. Morrison, and Timothy D. Veenstra

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Global Analysis of the Cortical Neuron Proteome, Li-Rong Yu, Thomas P. Conrads, Takuma Uo, Yoshito Kinoshita, Richard S. Morrison, David A. Lucas, King C. Chan, Josip Blonder, Haleem J. Issaq, and Timothy D. Veenstra

Submissions from 2003

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Anti-nociceptive and Anti-inflammatory Effects of the Methanol Extract of Annona senegalensis Root Bark, B. Adzu, Samson Amos, M. Adamu, and K. Gamaniel

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Anti-nociceptive and Anti-inflammatory Effects of the Methanol Extract of Annona senegalensis Root Bark, B. Adzu, Samson Amos, M. Adamu, and K. S. Gamaniel

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Evaluation of the Antidiarrhoeal Effects of Zizyphus spina-christi Stem Bark in Rats, B. Adzu, Samson Amos, M. B. Amizan, and K. Gamaniel

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Anti-inflammatory and Anti-nociceptive Effects of Sphaeranthus senegalensis, B. Adzu, Samson Amos, S. D. Kapu, and K. S. Gamaniel

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Hypotensive Activity of the Ethanol Extract of Pavetta crassipes Leaves, Samson Amos, Peter Achunike Akah, Lucy Binda, Nkechi Mercy Enwerem, Abiodun Ogundaini, Charles Wambebe, Isa Marte Hussaini, and Karniyus Shingu Gamaniel

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Effect of the Aqueous Extract of Chrysanthellum indicum on Calcium Mobilization and Activation of Rat Portal Vein, Samson Amos, L. Binda, M. Adamu, H. O. Vongtau, J. Abbah, E. K. I. Omogbai, P. A. Akah, B. B. Bukar, C. Wambebe, and K. Gamaniel

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Central Inhibitory Activity of the Aqueous Extract of Crinum giganteum, Samson Amos, L. Binda, P. Akah, C. Wambebe, and K. Gamaniel

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Neuropharmacological Effects of Hibiscus sabdariffa Aqueous Extract, Samson Amos, L. Binda, B. A. Chindo, A. Tseja, C. Wambebe, and K. Gamaniel

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Smooth Muscle Contraction Induced by Indigofera dendroides Leaf Extracts May Involve Calcium Mobilization via Potential Sensitive Channels, Samson Amos, L. Binda, O. F. Kunle, I. Okafor, M. Emeje, P. A. Akah, C. Wambebe, and K. Gamaniel

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Postsynaptic Dopamine (D2)-mediated Behavioural Effects of High Acute Doses of Artemisinin in Rodents, Samson Amos, B. A. Chindo, J. Abbah, H. O. Vongtau, I. Edmond, L. Binda, P. A. Akah, C. Wambebe, and K. S. Gamaniel

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Continuous Infusion as a Route of Administration in Embryo/Fetal Development Studies in the Rabbit, Melissa J. Beck, T. R. Gleason, C. S. Wally, C. P. Chengelis, D. G. Stump, and M. D. Nemec

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Developmental Toxicity Studies in Rats and Rabbits with DOV 21,947: A Triple Reuptake Inhibitor, Melissa J. Beck, D. G. Stump, M. D. Nemec, J. F. Holson, J. P. Tizzano, and J. Buelke-Sam

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Central Nervous System Activity of the Methanol Extract of Ficus platyphylla Stem Bark, B. A. Chindo, Samson Amos, A. A. Odutola, H. O. Vongtau, J. Abbah, C. Wambebe, and K. S. Gamaniel

Cancer Diagnosis Using proteomic Patterns, Thomas P. Conrads, Ming Zhou, Emmanuel F. Petricoin, Lance Liotta, and Timothy D. Veenstra

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A Comparison of MicroLC/Electrospray Ionization-MS and GC/MS for the Measurement of Stable Isotope Enrichment from a [2H2]-Glucose Metabolic Probe in T-Cell Genomic DNA, S. D. Fox, R. A. Lempicki, D. A. Hosack, M. W. Baseler, J. A. Kovacs, H. C. Lane, Timothy D. Veenstra, and H. J. Issaq

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Preinvasive and Invasive Ductal Pancreatic Cancer and its Early Detection in the Mouse, Sunil R. Hingorani, Emanuel F. Petricoin, Anirban Maitra, Vinodh Rajapakse, Catrina King, Michael A. Jacobetz, Sally Ross, Thomas P. Conrads, Timothy D. Veenstra, Ben A. Hitt, and et al

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Quantitative Proteomics Employing Primary Amine Affinity Tags, Van M. Hoang, Thomas P. Conrads, Timothy D. Veenstra, Josip Blonder, Atsushi Terunuma, Jonathan C. Vogel, and Robert J. Fisher

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Peer Reviewed: SELDI-TOF MS for Diagnostic Proteomics, Haleem J. Issaq, Thomas P. Conrads, DaRue A. Prieto, Radhakrishna Tirumalai, and Timothy D. Veenstra

Proteomic Patters: A Potential Test for Early Diagnosis of Ovarian Cancer, Haleem J. Issaq, Thomas P. Conrads, and Timothy D. Veenstra

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Effect of Experimental Parameters on the HPLC Separation of Peptides and Proteins, Haleem J. Issaq, Stephen D. Fox, Megha Mahadevan, Thomas P. Conrads, and Timothy D. Veenstra

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Development of a Two-Dimensional Protein-Peptide Separation Protocol for Comprehensive Proteome Measurements, George M. Janini, Thomas P. Conrads, Timothy D. Veenstra, and Haleem J. Issaq

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Development of a Two-Dimensional Protein-Peptide Separation Protocol for Comprehensive Proteome Measurements, George M. Janini, Thomas P. Conrads, Timothy D. Veenstra, and Haleem J. Issaq

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A Sheathless Nanoflow Electrospray Interface for On-Line Capillary Electrophoresis Mass Spectrometry, George M. Janini, Thomas P. Conrads, Kenneth L. Wilkens, Haleem J. Issaq, and Timothy D. Veenstra

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On-Column Sample Enrichment for Capillary Electrophoresis Sheathless Electrospray Ionization Mass Spectrometry: Evaluation for Peptide Analysis and Protein Identification, George M. Janini, Ming Zhou, Li-Rong Yu, Josip Blonder, Michelle Gignac, Thomas P. Conrads, Haleem J. Issaq, and Timothy D. Veenstra

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Novel Approaches to Visualization and Data Mining Reveals Diagnostic Information in the Low Amplitude Region of Serum Mass Spectra from Ovarian Cancer Patients, Donald J. Johann, Michael D. McGuigan, Stanimire Tomov, Vincent A. Fusaro, Sally Ross, Thomas P. Conrads, Timothy D. Veenstra, David A. Fishman, Gordon R. Whiteley, Emanuel F. Petricoin, and Lance A. Liotta

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Anti-Angiogenic Activity of Human Endostatin is HIF-1-Independent in Vitro and Sensitive to Timing of Treatment in a Human Saphenous Vein Assay, Gordon R. Macpherson, Sylvia S.W. Ng, Siiri L. Forbes, Giovanni Melillo, Tatiana Karpova, James McNally, Thomas P. Conrads, Timothy D. Veenstra, Alfredo Martinez, Frank Cuttitta, and et al

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Protein Phosphatase 2A Positively Regulates Ras Signaling by Dephosphorylating KSR1 and Raf-1 on Critical 14-3-3 Binding Sites, Stéphane Ory, Ming Zhou, Thomas P. Conrads, Timothy D. Veenstra, and Deborah K. Morrison

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1,3-Dinitrobenzene Inhibits Mitochondrial Complex II in Rat and Mouse Brainstem and Brainstem and Cortical Astrocytes, A. D. Phelka, Melissa J. Beck, and M. A. Philbert

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Profiling of Secreted Proteins from Human Ovarian Cancer Cell Lines by Surface-Enhanced Laser Desorption Ionization Time-of-Flight Mass Spectrometry, DaRue Prieto, Thomas P. Conrads, Dominic A. Scudiero, Timothy D. Veenstra, and Haleem J. Issaq

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High-Performance Separations and Mass Spectrometric Methods for High-Throughput Proteomics using accurate Mass Tags, Richard D. Smith, Gordon A. Anderson, Mary S. Lipton, Christophe Masselon, Ljiljana Paša-Tolic, Harold Udseth, Mikhail Belov, Yufeng Sheng, and Timothy D. Veenstra

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Characterization of the Low Molecular Weight Human Serum Proteome, Radhakrishna S. Tirumalai, King C. Chan, DaRue A. Prieto, Haleem J. Issaq, Thomas P. Conrads, and Timothy D. Veenstra

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The Depletion of Protein Signals in Metabonomics Analysis with the WET-CPMG Pulse Sequence, Que N. Van, Gwendolyn N. Chmurny, and Timothy D. Veenstra

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The Use of Urine Proteomic and Metabonomic Patterns for the Diagnosis of Interstitial Cystitis and Bacterial Cystitis, Que N. Van, John R. Klose, David A. Lucas, DaRue A. Prieto, Brian Luke, Jack Collins, Stanley K. Burt, Gwendolyn N. Chmurny, Haleem J. Issaq, Thomas P. Conrads, Timothy D. Veenstra, and Susan K. Keay

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Proteome Analysis of Posttranslational Modifications, Timothy D. Veenstra

Serum Protein Fingerprinting, Timothy D. Veenstra and Thomas P. Conrads

Phosphoproteomics, Timothy D. Veenstra and T. P. Conrads

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Evaluation of Liquid Chromatography–Mass Spectrometry for Routine Proteome Analyses, Li-Rong Yu, Haleem J. Issaq, Thomas P. Conrads, Takuma Uo, Josip Blonder, George m. Janini, Richard S. Morrison, and Timothy D. Veenstra

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Diagnostic Proteomics: Serum Proteomic Patterns for the Detection of Early Stage Cancers, Li-Rong Yu, Ming Zhou, Thomas P. Conrads, and Timothy D. Veenstra

New Tools for Quantitative Phosphoproteome Analysis, L. R. Yu and Timothy D. Veenstra

Submissions from 2002

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Pharmacological Evidence Favouring the Folkloric Use of Diospyros mespiliformis Hochst in the Relief of Pain and Fever, B. Adzu, Samson Amos, S. Dzarma, I. Muazzam, and K. S. Gamaniel

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Effect of Zizyphus spina-christi Willd Aqueous Extract on the Central Nervous System in Mice, B. Adzu, Samson Amos, S. Dzarma, C. Wambebe, and K. Gamaniel

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Neuropharmacological Screening of Diospyros mespiliformis in Mice, B. Adzu, Samson Amos, I. Muazzam, U. S. Inyang, and K. S. Gamaniel

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Behavioural Effects in Rodents of Methyl Angolensate: a Triterpenoid Isolated from Entandrophragma angolense, Samson Amos, Orisadipe Abayomi, Lucy Binda, Emeje Martins, Adesomoju Akinbobola, Joseph Okogun, Peter Akah, Charles Wambebe, and Karniyus Gamaniel

Preliminary Studies on Anti-inflammatory and Anti-nociceptive Effects of the Aqueous Extract of Chrysanthellum indicum, Samson Amos, M. Adamu, L. Binda, I. Edmond, O. F. Kunle, P. Akah, C. Wambebe, and K. Gamaniel

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Uterotonic Properties of the Ethanol Extract of Brysocarpus coccineus, Samson Amos, L. Binda, O. F. Kunle, C. Wambebe, and K. Gamaniel

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Anti-Inflammatory and Anti-Nociceptive Effects of Ficus platyphylla Extract in Mice and Rats, Samson Amos, B. A. Chindo, I. Edmond, P. Akah, C. Wambebe, and K. Gamaniel

Validation of Peripheral Tissue Cholinesterase Activity Assessment in Rats Administered Chlorpyrifos by Gavage, Melissa J. Beck, M. D. Nemec, G. J. Schaefer, D. G. Stump, and J. Buelke-Sam

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Low-Energy Collision-Induced Dissociation Fragmentation Analysis of Cysteinyl-Modified Peptides, Oleg V. Borisov, Michael B. Goshe, Thomas P. Conrads, V. Sergey Rakov, Timothy D. Veenstra, and Richard D. Smith

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An Accurate Mass Tag Strategy for Quantitative and High Throughput Proteome Measurements, Thomas P. Conrads, Haleem J. Issaq, and Timothy D. Veenstra

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New Tools for Quantitative Phosphoproteome Analysis, Thomas P. Conrads, Haleem J. Issaq, and Timothy D. Veenstra

High-Throughput, Quantitative Proteomics of Intact and Proteolytically Digested Proteins, T. P. Conrads, G. A. Anderson, D. J. Anderson, M. E. Belov, R. Harkewicz, M. S. Lipton, C. Masselon, L. Paša-Tolic, Y. Shen, H. R. Udseth, R. D. Smith, and Timothy D. Veenstra

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Phosphoprotein Isotope-Coded Affinity Tags: Application to the Enrichment and Identification of Low-Abundance Phosphoproteins, Michael B. Goshe, Timothy D. Veenstra, Ellen A. Panisko, Thomas P. Conrads, Nicolas H. Angell, and Richard D. Smith

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Methods for Fractionation, Separation and Profiling of Proteins and Peptides, Haleem J. Issaq, Thomas P. Conrads, George M. Janini, and Timothy D. Veenstra

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The SELDI-TOF MS Approach to Proteomics: Protein Profiling and Biomarker Identification, Haleem J. Issaq, Timothy D. Veenstra, Thomas P. Conrads, and Donna Felschow

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Selective Incorporation of Isotopically Labeled Amino Acids for Identification of Intact Proteins on a Proteome-Wide Level, Suzana Martinović, Timothy D. Veenstra, Gordon A. Anderson, Ljiljana Pasa-Tolić, and Richard D. Smith

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Proteomic Analysis in the Neurosciences, Richard S. Morrison, Yoshito Kinoshita, Mark D. Johnson, Takuma Uo, Joseph T. Ho, Joshua K. McBee, Thomas P. Conrads, and Timothy D. Veenstra

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The Postgenomic Age: Characterization of Proteomes, Ellen A. Panisko, Thomas P. Conrads, Michael B. Goshe, and Timothy D. Veenstra

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Potential Role of Mitochondrial Complex II in the Differential CNS Sensitivity to 1,3-Dinitrobenzene-Induced Encephalopathy, A. D. Phelka, Melissa J. Beck, and M. A. Philbert

Advanced Mass Spectrometric Approaches for Rapid and Quantitative Proteomics, R. D. Smith, G. A. Anderson, P. K. Jensen, M. S. Lipton, L. Paša-Tolic, and Timothy D. Veenstra

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An Accurate Mass Tag Strategy for Quantitative and High-Throughput Proteome Measurements, Richard D. Smith, Gordon A. Anderson, Mary S. Lipton, Ljiljana Pasa-Tolic, Yufeng Shen, Thomas P. Conrads, Timothy D. Veenstra, and Harold R. Udseth

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A Method to Evaluate Tryptic Digestion Efficiency for High-Throughput Proteome Analyses, Susan K. Wierenga, Mark J. Zocher, Matthew M. Mirus, Thomas P. Conrads, Michael B. Goshe, and Timothy D. Veenstra

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Proteome Analysis of Camptothecin-Treated Cortical Neurons Using Isotope-Coded Affinity Tags, Li-Rong Yu, Mark D. Johnson, Thomas P. Conrads, Richard D. Smith, Richard S. Morrison, and Timothy D. Veenstra

Submissions from 2001

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Antidiarrhoeal Activity of the Aqueous Extract of Terminalia avicennoides Roots, A. L. Abdullahi, M. O. Agho, Samson Amos, K. S. Gamaniel, and C. Wambebe

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Antinociceptive Activity of Zizyphus spina-christi Root Bark Extract, B. Adzu, Samson Amos, C. Wambebe, and K. Gamaniel

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Neuropharmacological Effect of the Aqueous Extract of Sphaeranthus senegalensis in Mice, Samson Amos, B. Adzu, L. Binda, C. Wambebe, and K. Gamaniel

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Cardiovascular Effects of the Aqueous Extract of Chrysanthellum indicum, Samson Amos, L. Binda, M. Adamu, C. Wambebe, and K. Gamaniel

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Behavioral Effects of the Aqueous Extract of Guiera senegalensis in Mice and Rats, Samson Amos, E. Kolawole, P. Akah, C. Wambebe, and K. Gamaniel

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Mitochondria in Migrating Neural Crest Cells are Sensitive to Ethanol-Induced Loss of Mitochondrial Transmembrane Potential, Melissa J. Beck, C. Harris, and M. A. Philbert

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Spatial Glutathione and Cysteine Distribution and Chemical Modulation in the Early Organogenesis Stage Rat Conceptus In Utero, Melissa J. Beck, C. McLellan, R. L.-F. Lightle, M. A. Philbert, and C. Harris

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Design and Performance of an ESI Interface for Selective External Ion Accumulation Coupled to a Fourier Transform Ion Cyclotron Mass Spectrometer, Mikhail E. Belov, Evgenii N. Nikolaev, Gordon A. Anderson, Harold R. Udseth, Thomas P. Conrads, Timothy D. Veenstra, Christophe D. Masselon, Mikhail V. Gorshkov, and Richard D. Smith

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Pharmacological Activity of the Methanolic Extract of Cassia nigricans Leaves, F. C. Chidume, K. Gamaniel, Samson Amos, P. Akah, O. Obodozie, and C. Wambebe

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Quantitative Analysis of Bacterial and Mammalian Proteomes Using a Combination of Cysteine Affinity Tags and 15N-Metabolic Labeling, Thomas P. Conrads, Kim Alving, Timothy D. Veenstra, Mikhail E. Belov, Gordon A. Anderson, David J. Anderson, Mary S. Lipton, Lijliana Pasa-Tolić, Harold R. Udseth, William B. Chrisler, Brian D. Thrall, and Richard D. Smith

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Phosphoprotein Isotope-Coded Affinity Tag Approach for Isolating and Quantitating Phosphopeptides in Proteome-Wide Analyses, Michael B. Goshe, Thomas P. Conrads, Ellen A. Panisko, Nicolas H. Angell, Timothy D. Veenstra, and Richard D. Smith

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A New Squalene-derived Epoxy tri-THF diol from Spathelia glabrescens, Wayne W. Harding, Denise S. Simpson, Helen Jacobs, Stewart McLean, and William F. Reynolds

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Spasmolytic Activity of Methyl Angolensate: A Triterpenoid Isolated from Entandrophragma angolense, A. Orisadipe, Samson Amos, A. Adesomoju, L. Binda, M. Emeje, J. Okogun, C. Wambebe, and K. Gamaniel